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Article Dans Une Revue Journal of the American Chemical Society Année : 2023

trans -Hydroalkynylation of Internal 1,3-Enynes Enabled by Cooperative Catalysis

Résumé

A cooperative catalyst system involving a Pd(0)/Senphos complex, tris(pentafluorophenyl)borane, copper bromide, and an amine base, is demonstrated to catalyze trans-hydroalkynylation of internal 1,3-enynes. For the first time, a Lewis acid catalyst is shown to promote the reaction involving the emerging outer-sphere oxidative reaction step. The resulting cross-conjugated dieneynes are versatile synthons for organic synthesis, and their characterization reveals distinct photophysical properties depending on the positioning of the donor/acceptor substituents along the conjugation path.
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Dates et versions

hal-04226610 , version 1 (03-10-2023)

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Ziyong Wang, Chen Zhang, Jason Wu, Bo Li, Anna Chrostowska, et al.. trans -Hydroalkynylation of Internal 1,3-Enynes Enabled by Cooperative Catalysis. Journal of the American Chemical Society, 2023, 145 (10), pp.5624-5630. ⟨10.1021/jacs.3c00514⟩. ⟨hal-04226610⟩
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