Article Dans Une Revue Free Radical Biology and Medicine Année : 2025

Temporal dynamics of oxylipins and antioxidant metabolites in rainbow trout muscle are driven by diet type rather than methylmercury or selenomethionine supplementation

Résumé

Tuna by-products in aquafeed pose challenges due to heavy metals like mercury (Hg), which has pro-oxidant effects. However, they also contain selenium (Se), an antioxidant oligoelement. This study assessed the oxidative impact of these elements in juvenile rainbow trout over a 6-month feeding trial. Fish were fed plant-based or tuna-based diets, with or without supplementation of methylmercury (MeHg) and selenomethionine (SeMet). Muscle samples were collected at 0, 21, 84, and 168 days to analyze fatty acid profiles, non-enzymatic oxylipins, and antioxidant metabolites (glutathione, vitamin E). Tuna-fed fish exhibited higher oxylipin levels and lower antioxidant metabolites compared to plant-fed fish. Notably, oxylipin levels remained elevated at 84 and 168 days in tuna-fed fish, correlating with a decrease in the GSH:GSSG ratio. In contrast, plant-fed fish showed a transient increase in oxylipins at 84 days, which normalized by day 168, aligning with a temporary drop in the GSH:GSSG ratio. MeHg and SeMet supplementation did not alter these trends. Surprisingly, these findings, along with a previous study, suggest that prolonged oxidative stress in tuna-fed fish is more closely linked to Se bioaccumulation than Hg. Future work should investigate dietary Se concentration and form to better understand these results.

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hal-05225823 , version 1 (27-08-2025)

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Marius Bidon, Cécile Heraud, Claudia Marchán-Moreno, Laurence Larroquet, Guillaume Reversat, et al.. Temporal dynamics of oxylipins and antioxidant metabolites in rainbow trout muscle are driven by diet type rather than methylmercury or selenomethionine supplementation. Free Radical Biology and Medicine, 2025, 239, pp.417-431. ⟨10.1016/j.freeradbiomed.2025.07.043⟩. ⟨hal-05225823⟩
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