Article Dans Une Revue Inorganic Chemistry Année : 2025

Multinuclear Silver(I)–Selenium Clusters Formation in Selenopeptides

Tshering Zangmo
  • Fonction : Auteur
Paulina Szczerba
  • Fonction : Auteur
Wojciech Bal

Résumé

The reactions of ionic silver (Ag+) with arginine vasopressin (AVP), a nonapeptide hormone cyclized by two cysteine residues, and its diselenium analogue was explored by an integrated LC-MS, UV-vis, and DFT approach. The replacement of Cys by SeCys in AVP increased the reactivity of the peptide toward Ag+ ions under mildly reducing conditions, with the formation of a Se4Ag4 cluster provided by Ag(I)-mediated dimerization of diselenide AVP. Specific electronic absorption bands confirmed the formation of the Ag4peptide2 complex, supported by DFT calculations. These results provide the first ever evidence that Ag(I) ions bind a selenopeptide and prefer SeCys over Cys as binding sites, opening a perspective on the involvement of selenobiomolecules in the emerging cellular toxicity of silver.

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lundi 16 novembre 2026
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Dates et versions

hal-05022734 , version 1 (16-11-2025)

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Tshering Zangmo, Paulina Szczerba, Ioannis Kanavos, Alejandro Gutiérrez-Quintanilla, Karinne Miqueu, et al.. Multinuclear Silver(I)–Selenium Clusters Formation in Selenopeptides. Inorganic Chemistry, 2025, 64 (11), pp.5348-5353. ⟨10.1021/acs.inorgchem.4c04867⟩. ⟨hal-05022734⟩
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