Synthesis of Allenes by Hydroalkylation of 1,3-Enynes with Ketones Enabled by Cooperative Catalysis - Université de Pau et des Pays de l'Adour Accéder directement au contenu
Article Dans Une Revue Journal of the American Chemical Society Année : 2023

Synthesis of Allenes by Hydroalkylation of 1,3-Enynes with Ketones Enabled by Cooperative Catalysis

Résumé

A method for the synthesis of allenes by the addition of ketones to 1,3-enynes by cooperative Pd(0)Senphos/B(C6F5)3/NR3 catalysis is described. A wide range of aryl- and aliphatic ketones undergo addition to various 1,3-enynes in high yields at room temperature. Mechanistic investigations revealed a rate-determining outer-sphere proton transfer mechanism, which was corroborated by DFT calculations.
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Dates et versions

hal-04252385 , version 1 (02-11-2023)

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Maxwell Eaton, Yuping Dai, Ziyong Wang, Bo Li, Walid Lamine, et al.. Synthesis of Allenes by Hydroalkylation of 1,3-Enynes with Ketones Enabled by Cooperative Catalysis. Journal of the American Chemical Society, 2023, 145 (39), pp.21638-21645. ⟨10.1021/jacs.3c08151⟩. ⟨hal-04252385⟩
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