Journal Articles Gut Pathogens Year : 2024

Power-law scaling in intratumoral microbiota of colorectal cancer

Nikolas Dovrolis
  • Function : Correspondent author
Maria Gazouli
  • Function : Correspondent author
Robert Whittaker
  • Function : Author
Thomas Matthews
  • Function : Author
Konstantinos Georgiou
  • Function : Author
George Theodoropoulos
  • Function : Author
Kostas Triantis
  • Function : Correspondent author

Abstract

It has recently been proposed that the study of microbial dynamics in humans may gain insights from island biogeographical theory. Here, we test whether the diversity of the intratumoral microbiota of colorectal cancer tumors (CRC) follows a power law with tumor size akin to the island species-area relationship. We confirm a direct correlation between the quantity of Amplicon Sequence Variants (ASVs) within CRC tumors and tumor sizes, following a (log)power model, explaining 47% of the variation. Understanding the processes involved, potentially through the analogy of tumors and islands, may ultimately contribute to future clinical and therapeutic strategies.
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hal-04925802 , version 1 (02-02-2025)

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Nikolas Dovrolis, Maria Gazouli, François Rigal, Robert Whittaker, Thomas Matthews, et al.. Power-law scaling in intratumoral microbiota of colorectal cancer. Gut Pathogens, 2024, 16 (1), pp.34. ⟨10.1186/s13099-024-00631-x⟩. ⟨hal-04925802⟩
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