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Article Dans Une Revue Inorganic Chemistry Année : 2023

Disclosing the Preferential Mercury Chelation by SeCys Containing Peptides over Their Cys Analogues

Résumé

Methylmercury, mercury (II), and mercury (I) chlorides were found to react with vasopressin, a nonapeptide hormone cyclized by two cysteine residues, and its mono- and diselenium analogues to form several mercury-peptide adducts. The replacement of Cys by SeCys in vasopressin increased the reactivity toward methylmercury, with the predominant formation of −Se/S–Hg–Se-bridged structures and the consequent demethylation of methylmercury. In competitive experiments, CH3HgCl reacted preferentially with the diselenium analogue rather than with vasopressin. The diselenium peptide also showed the capability to displace the CH3Hg moiety bound to S in vasopressin. These results open a promising perspective for the use of selenopeptides for methylmercury chelation and detoxification strategies.
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Dates et versions

hal-04224425 , version 1 (30-01-2024)

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Mikel Bernabeu de Maria, Diego Tesauro, Filippo Prencipe, Michele Saviano, Luigi Messori, et al.. Disclosing the Preferential Mercury Chelation by SeCys Containing Peptides over Their Cys Analogues. Inorganic Chemistry, 2023, 62 (37), pp.14980-14990. ⟨10.1021/acs.inorgchem.3c01708⟩. ⟨hal-04224425⟩
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