Size Effects in Finite Element Modelling of 3D Printed Bone Scaffolds Using Hydroxyapatite PEOT/PBT Composites - Université de Pau et des Pays de l'Adour Access content directly
Journal Articles Mathematics Year : 2021

Size Effects in Finite Element Modelling of 3D Printed Bone Scaffolds Using Hydroxyapatite PEOT/PBT Composites

Iñigo Calderon-Uriszar-Aldaca
  • Function : Author
Sergio Perez
Ravi Sinha
  • Function : Author
Maria Camara-Torres
  • Function : Author
Sara Villanueva
  • Function : Author
Carlos Mota
Alessandro Patelli
Lorenzo Moroni
Alberto Sanchez

Abstract

Additive manufacturing (AM) of scaffolds enables the fabrication of customized patient-specific implants for tissue regeneration. Scaffold customization does not involve only the macroscale shape of the final implant, but also their microscopic pore geometry and material properties, which are dependent on optimizable topology. A good match between the experimental data of AM scaffolds and the models is obtained when there is just a few millimetres at least in one direction. Here, we describe a methodology to perform finite element modelling on AM scaffolds for bone tissue regeneration with clinically relevant dimensions (i.e., volume > 1 cm3). The simulation used an equivalent cubic eight node finite elements mesh, and the materials properties were derived both empirically and numerically, from bulk material direct testing and simulated tests on scaffolds. The experimental validation was performed using poly(ethylene oxide terephthalate)-poly(butylene terephthalate) (PEOT/PBT) copolymers and 45 wt% nano hydroxyapatite fillers composites. By applying this methodology on three separate scaffold architectures with volumes larger than 1 cm3, the simulations overestimated the scaffold performance, resulting in 150–290% stiffer than average values obtained in the validation tests. The results mismatch highlighted the relevance of the lack of printing accuracy that is characteristic of the additive manufacturing process. Accordingly, a sensitivity analysis was performed on nine detected uncertainty sources, studying their influence. After the definition of acceptable execution tolerances and reliability levels, a design factor was defined to calibrate the methodology under expectable and conservative scenarios.

Dates and versions

hal-03860756 , version 1 (18-11-2022)

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Cite

Iñigo Calderon-Uriszar-Aldaca, Sergio Perez, Ravi Sinha, Maria Camara-Torres, Sara Villanueva, et al.. Size Effects in Finite Element Modelling of 3D Printed Bone Scaffolds Using Hydroxyapatite PEOT/PBT Composites. Mathematics , 2021, 9 (15), pp.1746. ⟨10.3390/math9151746⟩. ⟨hal-03860756⟩

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