For the performance assessment of a high radioactive waste underground repository, the excavation induced damage zone surrounding an underground drift as well as its evolution, particularly has been researched. After emplacing nuclear waste in underground cells, the disposal will be closed by the sealing system, in which the main element is the bentonite core. Ben-tonite core will offer a swelling pressure against the walls of underground drifts during the resaturation process. This study concentrates on the numerical analysis of the self-sealing of excavation induced damage zone under mechanical compression and hydration on the basis of a particular CDZ in-situ experiment, which has been made within the Meuse/Haute-Marne Underground Research Laboratory. This is the first time that the numerical modelling has been adopted for simulating the large scale self-sealing of the Callovo-Oxfordian claystone. In this study, a plastic damage model is applied to represent the mechanical behaviour of Callovo-Oxfordian claystone (COx). Meanwhile, a supplemented deformation model combined with the standard Biot model to represent the significant deformation of COx during water content changing. Computation of crack parameters (opening, orientation) and permeability of unsaturated fractured COx are performed using post-processing from damage variable in accordance with the fracture energy regularization and the cubic law, respectively. The validation of the proposed model is carried out by numerical simulation of: (1) COx sample deformation during a resaturation process under constant vertical stresses, (2) global water permeability tests of the self-sealing of a fractured COx sample during water injection, (3) CDZ in-situ experiment to describe the self-sealing of EDZ under mechanical compression and hydration. According to comparisons between the numerical and experimental findings, the capability of the proposed model to depict the self-sealing of the fractured COx claystone correctly, and the global water permeability of EDZ decrease in the resatura-tion process explains the accomplishment of the self-sealing of excavation induced damage zone. The present model is shown as a useful tool to evaluate the performance of nuclear waste disposal when taking into account the self-sealing process.