%0 Journal Article %T Varied effect of fortification of kale sprouts with novel organic selenium compounds on the synthesis of sulphur and phenolic compounds in relation to cytotoxic, antioxidant and anti-inflammatory activity %+ Université de Krakovie %+ IQOG-CSIC-Institute of organic chemistry (IQOG-CSIC), Madrid, Spain (IQOG-CSIC) %+ Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM) %+ The Hebrew University of Jerusalem (HUJ) %A Paśko, Paweł %A Galanty, Agnieszka %A Zagrodzki, Paweł %A Żmudzki, Paweł %A Bieniek, Urszula %A Prochownik, Ewelina %A Domínguez-Álvarez, Enrique %A Bierla, Katarzyna %A Lobinski, Ryszard %A Szpunar, Joanna %A Handzlik, Jadwiga %A Marcinkowska, Monika %A Gorinstein, Shela %< avec comité de lecture %@ 0026-265X %J Microchemical Journal %I Elsevier %V 179 %P 107509 %8 2022-04-25 %D 2022 %R 10.1016/j.microc.2022.107509 %K Anti-inflammation activity %K Cytotoxic activity %K Fortification %K Isothiocyanates %K Kale sprouts %K Novel selenium organic compounds %Z Chemical Sciences/Analytical chemistryJournal articles %X Selenium deficiency in daily diet is a common problem in many countries, thus searching for new dietary sources of this trace element is an important scientific challenge. Selenium biofortified sprouts from Brassicaceae family are good candidates for new dietary selenium source, as they reveal one of the highest capability to synthesize and accumulate this element. As a part of this extensive search, the influence of novel selenium organic compounds on fortification of kale sprouts biological activity was investigated. The present study is focused on the evaluation of the influence of these compounds on the synthesis of glucosinolates, isothiocyanates, indoles and phenolic acids in kale sprouts, together with the determination of their impact on antioxidant, anti-inflammatory and cytotoxic activity on gastrointestinal, prostate, and thyroid normal and cancer cells. The present study yields the conclusion that fortification of kale sprouts with selenium organic compounds bearing benzoselenoate scaffold influences the production of isothiocyanates, phenolic acids, and enhances the antioxidant properties of fortified sprouts. Notably, fortification with compounds based on benzoselenoate scaffold display chemoprotective properties in various cancer types (gastric, thyroid, and prostate cancer). The present study can facilitate the design of future agrochemicals. Compounds bearing benzoselenoate scaffold or selenyl phenylpiperazine motif seem to be particularly promising for these purposes. %G English %2 https://univ-pau.hal.science/hal-03689507/document %2 https://univ-pau.hal.science/hal-03689507/file/Varied%20effect%20of%20fortification%20of%20kale%20sprouts%20Microchemical%20Journal%202022.pdf %L hal-03689507 %U https://univ-pau.hal.science/hal-03689507 %~ CNRS %~ UNIV-PAU %~ IPREM %~ INC-CNRS %~ IPREM-CAPT %~ UPPA-OA %~ TEST2-HALCNRS