The industry has undergone various industrial revolutions leading to major upheavals in all activities of human life, particularly in the field of education. Technology has become ubiquitous in educational organizations seeking to respond effectively to the demand for improvement, optimization, and personalization of large-scale, technology-supported education. Possibilities for automatically tracking the progress of learners become possible, at least for assessing attendance, progress, and acquisition of knowledge or skills. Knowledge sources are increasingly heterogeneous and complex in learning environments. With continuous innovations in the way we teach and learn, there is a need to rethink and transform the model of integrating technology into teaching in order to achieve intelligent collaboration and coordination between technology and people for learning. In this article, we propose an approach to be taken into account in the natural evolution of educational institutions under the term of University 4.0. The University 4.0 concept is inspired by the Industry 4.0 paradigm and applies its concepts to higher education to provide better responses to the specific needs of each learner. This paper presents a state of the art on the Industry and Education revolutions and in particular the digital and pedagogical transformations in education from Education 3.0 to Education 4.0, as well as the challenges of University 4.0.