Multi-responsive biocompatible microgels with long term stability were synthesized by precipitation copolymerization of oligo(ethylene glycol) methyl ether methacrylate (OEGMA), di(ethylene glycol) methyl ether methacrylate (MEO2MA), methacrylic acid (MAA) and crosslinkers in aqueous dispersed media. Different crosslinkers, i.e. ethylene glycol dimethacrylate (EGDMA), oligo(ethylene glycol) diacrylate (OEGDA) or N,N-methylenebisacrylamide (MBA) were used for the synthesis of the microgels. The present work investigates for the first time how the inner structure of the biocompatible P(MEO2MA-co-OEGMA-co-MAA) microgels impacts their swelling-to-collapse transition in response to both temperature and pH. The EGDMA-crosslinked microgels obviously differ from the OEGDA- and MBA-crosslinked microgels. The OEGDA-crosslinked P(MEO2MA-co-OEGMA-co-MAA) microgels are ideal candidates to prepare robust thermoresponsive hybrid magnetic microgels by a straightforward method involving simple loading of pre-formed magnetic nanoparticles (NP) in the absence of NP release. The crosslinker distribution is at the origin of differences in the distribution of iron oxide nanoparticles. The homogeneous distribution of both MAA units and the OEGDA crosslinker in the P(MEO2MA-co-OEGMA-co-MAA) microgels ensured a sharp VPTT of microgels over a wide range of pH values (from pH 4 to 9) and the retention of the thermoresponsiveness of the corresponding hybrid microgels for the different contents of magnetic nanoparticles (from 7 to 33 wt% of γ-Fe2O3versus polymer). Turbidimetry measurements highlighted the unique stability of the hybrid microgels over several hours even for the highest content of iron oxide nanoparticles.