ROLLING PHASE MODULATION REGIME FOR DYNAMIC FULL FIELD OCT - Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris - PSL
Article Dans Une Revue Communications Biology Année : 2024

ROLLING PHASE MODULATION REGIME FOR DYNAMIC FULL FIELD OCT

Résumé

Dynamic full-field optical coherence tomography (DFFOCT) has recently emerged as an invaluable label-free microscopy technique, owing to its sensitivity to cell activity, as well as speed and sectioning ability. However, the quality of DFFOCT images are often degraded due to phase noise and fringe artifacts. In this work, we present a new implementation named Rolling-Phase (RP) DFFOCT, in which the reference arm is slowly scanned over magnitudes exceeding 2π. We demonstrate mathematically and experimentally that it shows superior image quality while enabling to extract both static and dynamic contrast simultaneously. We showcase RP DFFOCT on monkey retinal explant, and demonstrate its ability to better resolve subcellular structures, including intranuclear activity.
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Dates et versions

hal-04883678 , version 1 (13-01-2025)

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Tual Monfort, Kate Grieve, Olivier Thouvenin. ROLLING PHASE MODULATION REGIME FOR DYNAMIC FULL FIELD OCT. Communications Biology, 2024, 6, ⟨10.1364/opticaopen.27991811.v1⟩. ⟨hal-04883678⟩
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